Starting from nurse discussion activity in Aisyiyah / Muhammadiyah Nursing Academy, then it was agreed that we needed periodically discussion. In 1997, it has been held a panel forum of Aisyiyah Nursing Academy with Faculty of Medicine and Health Science of UMY attended by service institution in Muhammadiyah and Aisyiyah, including Nursing Academy of Islamic Hospital Jakarta. Prof. Ma’rifin Husin, the consortium of health science Education and Cultural Department has also attended the panel forum. Decision Letter No. 062/SK-UMY/IV/2000 about the appointment of Structural Office at Faculty of Health and Medicine of UMY at 11 April 2000 decided to establish Nursing Department at Faculty of Medicine and Health Science of UMY, therefore officially the activity moved to Sonopakis campus. Start from academic year 2002/2003 the learning activity moved to integrated campus at. Lingkar Selatan, Tamantirto, Kasihan, Bantul, Yogyakarta.
Nursing Department won the Competition Grants Program A1 from Directorate General of Higher Education and in 2005 Faculty of Medicine and Health Science has been accredited from National Accreditation Agency of Directorate General of Higher Education. In 2009 Health Science Department of Faculty of Medicine and Health Science of UMY got B accreditation and in 2015 got an A accreditation for the academic and profession from Independent Accreditation Agency of Health Science Education of Indonesia.
Nursing Study Program of The Faculty of Medicine and Health Sciences Universitas Muhammadiyah Yogyakarta is a unity of bachelor nursing and profession nurses academic program. In 2012, Nursing Study Program of The Faculty of Medicine and Health Sciences Universitas Muhammadiyah Yogyakarta began to implement full system block as its teaching approach in Competency Based Curriculum (KBK). Full block approach is expected to improve the quality of teaching and student competency of Nursing Study Program of The Faculty of Medicine and Health Sciences Universitas Muhammadiyah Yogyakarta.